THE ULTIMATE GUIDE TO NR1-SITE

Employing this approach, Kalbaugh et al. assigned affinity and efficacy roles to positions while in the LBDs of the NR1 and NR2A NMDAR subunits. In situ mutation of residues in direct contact with certain ligand influenced both efficacy and affinity, even though positions that stabilize the shut cleft conformation with no immediate ligand interacti